CRISPR Cas Genome Editors - from Bacteria to Biotech

Prof Martin Jínek

The CRISPR-Cas system constitutes a genome defence mechanism that protects bacteria from invasive genetic elements such as viruses. The system functions by using guide RNA molecules in conjunction with programmable nucleases such as Cas9 to recognize and cleave invader DNA. CRISPR-associated nucleases have been repurposed as powerful tools for precision genome editing in eukaryotic cells and organisms. My research aims to elucidate the molecular mechanisms of CRISPR-associated nucleases using a combination of structural, biochemical and biophysical approaches. These studies provide the foundation for understanding the molecular function of CRISPR genome editors and for the ongoing development of CRISPR-based genome editing for biotechnological and therapeutic applications.

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